![]() ![]() Tolerance: it is capacity of taking excessive does without producing toxic effect.Cumulative action of the drug: the frequency and dose of a drug administered depends upon the rate of excretion from the body.Weight: a person of overweight requires a large dose the usual one.Age: infants, children and the old requires smaller dosage of a drug than that of an adult.In this, the drug acts as an antigen and antibodies are produced. Allergic reaction: it is an unpredictable reaction to a drug.This occurs when a patient over react or under reacts to a drug or has a reaction different form the normal Idiosyncratic reaction: medicine may cause an idiosyncratic effect.Toxic effect: may develop after prolonged intake of a medication or when a medication accumulation in the blood because of impaired. ![]() For example, a client maybe becomes comatose when a drug is ingested
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